formspring me.

Monday, May 3, 2010

think again.

continue to insult or whatever, you people are best at but honestly its aint bringing me down or anything. i have been through the worst of my life so i know i grew stronger than before. since you all just wanna play with me then i would happy to play along too(: but something i just wish you people will get to experience what i had gone through cause perhaps thats the only way you people will stop insults others. just imagine the worst of everything, your closest friend cant even recongise you when they are standing just infront of your bed, your favorite niece call you a monster in your face, people giving you the most awful stares in your face trying tell you that you look digustingly horrible, you make kids cry just by looking at you, you dont know if you can pull it through the whole situation cause the doctors couldnt find out the cause of the illness & the list goes on.


i am not here to gain sympathy or what so ever you people can think off but seriously what can all this insults you give to others let you gain anything~ afterall everyone has flaws... nevermind shan explain to all you key board warriors anymore....


ohya! here's alittle bit of what steven jonhson syndrome is all about(:


Stevens–Johnson syndrome


is life-threatening condition affecting the skin in which cell death causes the epidermis to separate from the dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes. Although the majority of cases are idiopathic, the main class of known causes is medications, followed by infections and (rarely) cancers.


Recovery after Stevens-Johnson syndrome can take weeks to months, depending on the severity of your condition.




Causes




SJS is thought to arise due to a disorder of the immune system.
It can be caused by infections (usually following infections such as herpes simplex virus, influenza, mumps, cat-scratch fever, histoplasmosis, Epstein-Barr virus, mycoplasma pneumoniae or similar), adverse effects of drugs (allopurinol, diclofenac, etravirine, Isotretinoin, aka Accutane, fluconazole, valdecoxib, sitagliptin, oseltamivir, penicillins, barbiturates,sulfonamides, phenytoin, azithromycin, modafinil, lamotrigine, nevirapine, pyrimethamine, ibuprofen, ethosuximide, carbamazepine and gout medications), malignancy (carcinomasand lymphomas), or idiopathic factors (up to 50% of the time). SJS has also been consistently reported as an uncommon side effect of herbal supplements containing ginseng. SJS may also be caused by cocaine usage.
Although Stevens–Johnson Syndrome can be caused by viral infections, malignancies or severe allergic reactions to medication, the leading cause appears to be the use of antibiotics andsulfa drugs. Medications that have traditionally been known to lead to SJS, erythema multiforme and toxic epidermal necrolysis include sulfonamides (antibiotics), penicillins (antibiotics),barbiturates (sedatives), lamotrigine and phenytoin (e.g. Dilantin) (anticonvulsants). Combining lamotrigine with sodium valproate increases the risk of SJS.
Non-steroidal anti-inflammatory drugs are a rare cause of SJS in adults; the risk is higher for older patients, women and those initiating treatment. Typically, the symptoms of drug-induced SJS arise within a week of starting the medication. People with systemic lupus erythematosus or HIV infections are more susceptible to drug-induced SJS.

[edit]Genetics

In some East Asian populations studied (Han Chinese and Thai), carbamazepine- and phenytoin-induced SJS is strongly associated with HLA-B*1502 (HLA-B75), an HLA-B serotype of the broader serotype HLA-B15. A study in Europe suggested that the gene marker is only relevant for East Asians. Based on the Asian findings, similar studies were performed in Europe which showed 61% of allopurinol-induced SJS/TEN patients carried the HLA-B58 (B*5801 allele - phenotype frequency in Europeans is typically 3%). One study concluded "even when HLA-B alleles behave as strong risk factors, as for allopurinol, they are neither sufficient nor necessary to explain the disease."



Symptoms


SJS usually begins with fever, sore throat, and fatigue, which is misdiagnosed and usually treated with antibiotics. Ulcers and other lesions begin to appear in the mucous membranes, almost always in the mouth and lips but also in the genital and anal regions. Those in the mouth are usually extremely painful and reduce the patient's ability to eat or drink. Conjunctivitis of the eyes occurs in about 30% of children who develop SJS. A rash of round lesions about an inch across arises on the face, trunk, arms and legs, and soles of the feet, but usually not the scalp.


i wont be posting pictures of it cause is just to much to a person sight but if you really want to view them just goggled it(: it was like near death~ i never one to be that close to death never again.

No comments: